A Noninvasive Future – Prenatal Genetic Testing Looks to Single-Cell Methods as the Next Frontier

Author Archives: WebMast

A Noninvasive Future – Prenatal Genetic Testing Looks to Single-Cell Methods as the Next Frontier

ClinicalOmics By Helen Albert|August 2017 Prenatal genetic testing has advanced enormously over the last few decades. Amniocentesis and chorionic villus sampling (CVS) have been performed to diagnose fetal abnormalities for many years, but these tests are invasiveand not without problems. The risk for miscarriage is low (approximately 1 in 1000 for amniocentesis and 1 in 500 […]

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Fetal cells in maternal blood for prenatal diagnosis: a love story rekindled

Biomark Med. 2017 Jun 15 Singh R, Hatt L, Ravn K, Vogel I, Petersen OB, Uldbjerg N, Schelde P For decades it has been common knowledge that some cells from the developing fetus make their way into maternal circulation, and that this process starts in the early weeks of first trimester. Naturally, when alternative technologies for prenatal diagnosis were being explored, the use of […]

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Arcedi Biotech aims to advance prenatal testing to whole genome, noninvasively

BioMed WorldTech By Katie Pfaff|July 11, 2017 Arcedi Biotech ApS provides noninvasive cell-based prenatal testing options beyond traditional methods, like amniocentesis. The Vejle, Denmark-based company’s technology isolates maternal and fetal cells for more comprehensive testing and rare cell detection in fetal samples. “This is going to be the first cell-based noninvasive prenatal test that is […]

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News and Notes from PNDx 2016 (Diagnostics World News)

By Benjamin Ross|December 9, 2016 The fourth annual Advances in Prenatal Molecular Diagnostics Conference took place last week in Cambridge, Massachusetts. The conference focused the bulk of its efforts on addressing two important, parallel issues: the science involved in cell-free vs. circulating fetal cells, and the angle of genetic counseling that impacts both the patient and […]

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Fetal Cell-Based Noninvasive Prenatal Testing Advances With Three New Feasibility studies (GenomeWeb)

By Julia Karow|Nov 02, 2016|NEW YORK Prenatal testing appears to be at the brink of another round of major innovation, with three recent reports demonstrating the feasibility of isolating fetal cells noninvasively and analyzing their DNA for aberrations, a goal researchers had pursued for decades. Testing DNA from fetal cells instead of cell-free DNA from the mother’s blood […]

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Genome-wide copy number analysis on DNA from fetal cells isolated from the blood of pregnant women. Prenat Diagn. 2016

Prenat Diagn. 2016 Oct 19 Kølvraa S1, Singh R1, Normand EA2, Qdaisat S2, van den Veyver IB2,3, Jackson L4, Hatt L1, Schelde P1, Uldbjerg N5, Vestergaard EM6, Zhao L2, Chen R2, Shaw CA2, Breman AM2, Beaudet AL2.   Abstract OBJECTIVE: Non-invasive prenatal testing (NIPT) based on fetal cells in maternal blood has the advantage over NIPT based on circulating cell-free fetal DNA in that there is no contamination with maternal DNA. This […]

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Fetal Cells Offer Promise in Prenatal Testing (MIT Technology Review)

A scientist says a blood test that can discern a fetus’s entire genome is coming by Bonnie Rochman|August 18, 2016 The year Led Zeppelin released its first album, in 1969, doctors in California found that they could sometimes spot Y chromosomes in some cells collected from a pregnant woman’s blood. It meant the cells came from […]

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Video – ARCEDI Biotech at the ‘Prague Spring Sympoisum’

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Bagger-Sørensen-selskab vil lancere fostertest i år (MedWatch)

Af Lonni Lynge|18 April 2016 Danske Arcedi Biotech, der er ejet af Bagger-Sørensen-familien, har udviklet en test som gennem en blodprøve kan fastslå, om et ufødt barn har genetiske fejl. ARCEDI forventer at indtage det amerikanske marked senere i år READ MORE

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A new marker set that identifies fetal cells in maternal circulation with high specificity. Prenat Diagn. 2014. June; 34:1-7.

Prenat Diagn. 2014 Nov;34(11):1066-72 Hatt L1, Brinch M, Singh R, Møller K, Lauridsen RH, Schlütter JM, Uldbjerg N, Christensen B, Kølvraa S. Abstract OBJECTIVE: Fetal cells from the maternal circulation (FCMBs) have the potential to replace cells from amniotic fluid or chorionic villi in a diagnosis of common chromosomal aneuploidies. Good markers for enrichment and identification are lacking. METHOD: Blood samples from 78 normal pregnancies were […]

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