By Benjamin Ross|December 9, 2016 The fourth annual Advances in Prenatal Molecular Diagnostics Conference took place last week in Cambridge, Massachusetts. The conference focused the bulk of its efforts on addressing two important, parallel issues: the science involved in cell-free vs. circulating fetal cells, and the angle of genetic counseling that impacts both the patient and […]read more
Fetal Cell-Based Noninvasive Prenatal Testing Advances With Three New Feasibility studies (GenomeWeb)
By Julia Karow|Nov 02, 2016|NEW YORK Prenatal testing appears to be at the brink of another round of major innovation, with three recent reports demonstrating the feasibility of isolating fetal cells noninvasively and analyzing their DNA for aberrations, a goal researchers had pursued for decades. Testing DNA from fetal cells instead of cell-free DNA from the mother’s blood […]read more
Genome-wide copy number analysis on DNA from fetal cells isolated from the blood of pregnant women. Prenat Diagn. 2016
Prenat Diagn. 2016 Oct 19 Kølvraa S1, Singh R1, Normand EA2, Qdaisat S2, van den Veyver IB2,3, Jackson L4, Hatt L1, Schelde P1, Uldbjerg N5, Vestergaard EM6, Zhao L2, Chen R2, Shaw CA2, Breman AM2, Beaudet AL2. Abstract OBJECTIVE: Non-invasive prenatal testing (NIPT) based on fetal cells in maternal blood has the advantage over NIPT based on circulating cell-free fetal DNA in that there is no contamination with maternal DNA. This […]read more
A scientist says a blood test that can discern a fetus’s entire genome is coming by Bonnie Rochman|August 18, 2016 The year Led Zeppelin released its first album, in 1969, doctors in California found that they could sometimes spot Y chromosomes in some cells collected from a pregnant woman’s blood. It meant the cells came from […]read more
Af Lonni Lynge|18 April 2016 Danske Arcedi Biotech, der er ejet af Bagger-Sørensen-familien, har udviklet en test som gennem en blodprøve kan fastslå, om et ufødt barn har genetiske fejl. ARCEDI forventer at indtage det amerikanske marked senere i år READ MOREread more
A new marker set that identifies fetal cells in maternal circulation with high specificity. Prenat Diagn. 2014. June; 34:1-7.
Prenat Diagn. 2014 Nov;34(11):1066-72 Hatt L1, Brinch M, Singh R, Møller K, Lauridsen RH, Schlütter JM, Uldbjerg N, Christensen B, Kølvraa S. Abstract OBJECTIVE: Fetal cells from the maternal circulation (FCMBs) have the potential to replace cells from amniotic fluid or chorionic villi in a diagnosis of common chromosomal aneuploidies. Good markers for enrichment and identification are lacking. METHOD: Blood samples from 78 normal pregnancies were […]read more
Characterization of Fetal Cells from the Maternal Circulation by Microarray Gene Expression Analysis – Could the Extravillous Trophoblasts Be a Target for Future Cell-Based Non-Invasive Prenatal Diagnosis? Fetal Diagn Ther. 2013 Nov 9
Fetal Diagn Ther. 2014;35(3):218-27 Hatt L, Brinch M, Singh R, Møller K, Lauridsen RH, Uldbjerg N, Huppertz B, Christensen B, Kølvraa S. Abstract INTRODUCTION: Circulating fetal cells in maternal blood provide a tool for risk-free, non-invasive prenatal diagnosis. However, fetal cells in the maternal circulation are scarce, and to effectively isolate enough of them for reliable diagnostics, it is crucial to know which fetal cell type(s) […]read more
Af Tina Bryld|1 June 2014 Forskning: En gruppe forskere på Aarhus Universitetshospital, Skejby, har fundet ud af, hvordan man kan fiske fosterceller ud af en blodprøve fra moderen, så man fremover gennem den kan tjekke fosteret for misdannelser. READ MOREread more
Identification of circulating fetal cell markers by microarray analysis. Prenat Diagn. 2012 Aug;32(8):742-51.
Prenat Diagn. 2012 Aug;32(8):742-51 Brinch M1, Hatt L, Singh R, Møller K, Sommer S, Uldbjerg N, Christensen B, Kølvraa S. Abstract OBJECTIVE: Different fetal cell types have been found in the maternal blood during pregnancy in the past, but fetal cells are scarce, and the proportions of the different cell types are unclear. The objective of the present study was to identify specific fetal cell […]read more