Commentary on a combined approach to the problem of developing biomarkers for the prediction of spontaneous preterm labor that leads to preterm birth

Introduction: Globally, preterm birth has replaced congenital malformation as the major cause of perinatal mortality and morbidity. The reduced rate of congenital malformation was not achieved through a single bio- physical or biochemical marker at a specific gestational age, but rather through a combination of clinical, bio- physical and biochemical markers at different gestational ages. …

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