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Danish biotech company: Launch of pioneering blood test with genetic profile of the fetus

The Danish biotech company, Arcedi Biotech, announces the launch of Evita test completeTM, a technology that will revolutionize the choices available for pregnant women who want to get a clear genetic overview of their unborn child. The test looks for serious chromosomal aberrations – using nothing else than a blood sample. Gå til Dansk artikel …

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The story behind a new test: When perseverance leads to great achievements

“I have always had an appetite for impossible tasks”, said the late Professor Steen Kølvraa when interviewed for a Danish newspaper six years ago when he talked about the research team’s progress in their endeavors to identify and isolate fetal cells in maternal blood.  Gå til Dansk artikel At the time, Steen Kølvraa had been …

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Cell-based non-invasive prenatal testing for monogenic disorders: confirmation of unaffected fetuses following preimplantation genetic testing

Purpose: Proof of concept of the use of cell-based non-invasive prenatal testing (cbNIPT) as an alternative to chorionic villus sampling (CVS) following preimplantation genetic testing for monogenic disorders (PGT-M). Method: PGT-M was performed by combined testing of short tandem repeat (STR) markers and direct mutation detection, followed by transfer of an unaffected embryo. Patients who …

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Hydatidiform mole diagnostics using circulating gestational trophoblasts isolated from maternal blood

Background: In gestational trophoblastic disease, the prognosis is related to the genetic constitution. In some cases, taking a biopsy is contraindicated. Methods: In a pregnant woman, ultrasound scanning suggested hydatidiform mole. To explore if the genetic constitution can be established without taking a biopsy (or terminating the pregnancy), cell-free DNA and circulating gestational trophoblasts were …

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The Number of Circulating Fetal Extravillous Trophoblasts Varies from Gestational Week 6 to 20

Cell-based non-invasive prenatal testing (cbNIPT) based on circulating fetal extravillous trophoblasts (fEVTs) has shown to be possible in gestational week (GW) 10–13. Prenatal testing is relevant for a wider time period than GW10–13, but it is unclear if fEVTs are present in sufficient numbers for cbNIPT at other time points during pregnancy.  We present the …

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