Ripudaman Singh

mRNA and Protein Expression in Human Fetal Membrane Cells: Potential Biomarkers for Preterm Prelabor Rupture of the Fetal Membranes?

Abstract: Clinically, unique markers in fetal membrane cells may contribute to the search for biomarkers for preterm prelabor rupture of the fetal membranes (pPROM) in maternal blood. pPROM is associated with overwhelming inflammation and premature cellular senescence causing “biological microfractures” of the fetal membranes. We hypothesize that these pathological processes are associated with the shedding …

mRNA and Protein Expression in Human Fetal Membrane Cells: Potential Biomarkers for Preterm Prelabor Rupture of the Fetal Membranes? Read More »

Diagnosis of hydatidiform moles using circulating gestational trophoblasts isolated from maternal blood

Introduction: Identifying hydatidiform moles (HMs) is crucial due to the risk of gestationaltrophoblastic neoplasia. When a HM is suspected on clinical findings, surgical termination isrecommended. However, in a substantial fraction of the cases, the conceptus is actually a nonmolar miscarriage. If distinction between molar and non-molar gestations could be obtainedbefore termination, surgical intervention could be …

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Noninvasive prenatal screening for cystic fibrosis using circulating trophoblasts: Detection of the 50 most common disease‐causing variants

Objectives: Cystic fibrosis (CF) is one of the most common severe autosomal recessive disorders. Prenatal or preconception CF screening is offered in some countries. A maternal blood sample in early pregnancy can provide circulating trophoblasts and offers a DNA source for genetic analysis of both the mother and the fetus. This study aimed to develop …

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Cell-Based NIPT Detects 47,XXY Genotype in a Twin Pregnancy

Background: The existing risk of procedure-related miscarriage following invasive sampling for prenatal diagnosis is higher for twin pregnancies and some women are reluctant to test these typically difficultly obtained pregnancies invasively. Therefore, there is a need for noninvasive testing options that can test twin pregnancies at an earlygestational age and ideally test the twins individually. …

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Presentation at CoGEN-2021

Line Dahl Jeppesen presents her PhD project at CoGEN-2021 meeting Line Dahl Jeppesen who is doing her PhD at ARCEDI Biotech presented a talk at the 8th CoGEN meeting on her research focusing on non-invasive prenatal diagnosis of monogenic disorders using circulating fetal cells. The PhD project is being conducted in collaboration with Aarhus University Hospital, Aalborg University Hospital, …

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ARCEDI CSO presents EVITA TEST COMPLETE at an event in Aarhus University

ARCEDI Chief Scientific Officer, Lotte Hatt presented EVITA TEST COMPLETE at a debate event organised at Aarhus University on the future of healthcare in the Central Denmark Region. Future of Healthcare in the Central Denmark Region   In connection with the upcoming elections in the Central Denmark Region scheduled for November 16, a debate event …

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Screening for Fetal Aneuploidy and Sex Chromosomal Anomalies in a Pregnant Woman With Mosaicism for Turner Syndrome—Applications and Advantages of Cell-Based NIPT

Background: Cell-free NIPT and cell-based NIPT are risk-free testing options using maternal blood samples to screen for fetal aneuploidies, but the methods differ. For cell-free NIPT, the fetal fraction of cell-free DNA in plasma is analyzed with a highbackground of maternal DNA. In contrast, for cell-based NIPT, a limited number of the rare, intact fetal …

Screening for Fetal Aneuploidy and Sex Chromosomal Anomalies in a Pregnant Woman With Mosaicism for Turner Syndrome—Applications and Advantages of Cell-Based NIPT Read More »

ARCEDI CTO features in ‘Digital Hub Denmark’

ARCEDI, and Chief Technology Officer Ripudaman Singh gets featured in the ‘Tech Talent’ campaign by Digital Hub Danmark Ripudaman Singh, India   The contrasts between India and Denmark are big, but the small country to the North could provide Ripudaman Singh with some interesting opportunities. 20 years ago, the 45-year-old CTO landed in Aarhus, where …

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